Grapefruit Haze was created to marry grapefruit flavor and hardy genetics from an F4 Grapefruit male with the bud density, spicy taste, and traditional characteristics of a Haze female. Canadian breeder Next Generation Seed Company made the match.

Grapefruit Haze is said to smell and taste like fruits and peppery spice.

The strain was named the highest THC level at the 2013 Spannibis Expo in Barcelona.